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doi: 10.3389/fcvm.2025.1638747 Received 31 May 2025 Accepted 29 July 2025 Published 12 August 2025 Volume 12 - 2025 Edited by Alicia Del Saz Lara, University of Castilla-La Mancha, Spain Reviewed by Binaya Basyal, MedStar Washington Hospital Center, United States Taner Ulus, Eskiehir Osmangazi University, Trkiye Updates Copyright 2025 Deng, Li, Li, Li, Cheng and Xiao

Concurrently, a spectrum of inflammatory mediatorsincluding cytokines, chemokines, and proteasesis released, collectively establishing a persistent pro-inflammatory microenvironment that sustains disease progression ( In recent years, targeted studies have further unraveled the complex regulatory mechanisms of chronic inflammation in COPD, spanning molecular pathways, cellular effects, animal models, microecological balance, and immune defense

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NAC application elevated the protein levels of p35, the neuronal-specific activator of Cdk5, thereby enhancing Cdk5 activity

Injection site reactions (mild redness, transient swelling) are the most common, typically resolving within 24 hours

Ammonia levels and hepatic encephalopathy in patients with known chronic liver disease