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Given that ARID1A-negative cancer cells have been previously shown to be more susceptible to inhibition of glutathione synthesis compared to ARID1A-positive cancer cells, we next sought to determine whether EN25 selectively impairs cell viability of ARID1A-negative A2780 ovarian cancer cells, compared to ARID1A-positive RMG-1 ovarian cancer cells

A recent 2022 study demonstrated that not only neurons but also glial cells rely on glutathione for homeostasis (12)

Furthermore, FA metabolism and lipid droplet dynamics have both been implicated in regulating longevity through modulation of availability of certain FAs and lipophilic hormones such as dafachronic acid and pregnenolone which delay aging in C

Then, the cartridge was dried under vacuum with a defined nitrogen flow (5.0, Nippon Gases, Dsseldorf, Germany) for approximately 25 min