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Whilst we found that ex vivo vehicle treated cells produced high levels of cytokines, including IL-5, IL-13, IL-9 ( Supplementary Figures 4BD ), and modest amounts of IL-10 and IL-6 ( Supplementary Figures 4E, F ), melatonin treatment greatly reduced the concentration of all cytokines analyzed ( Supplementary Figures 4B F )

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the antibodies can be used alone in the treatment of cancers, or in various embodiments uses of the antibodies include, but are not limited to: payload delivery e.g., drug, siRNA, mRNA, cytokine, radionuclide ALPPL2 is expressed specifically by several types of incurable cancer but not normal human tissues except for placental trophoblasts