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A rejection, delay, label limitation, or additional trial requirement would also matter

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For standard review, the FDA targets a 10-month review period from the acceptance of the NDA submission

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Chronic activation of these glial cells drives neuroinflammatory processes that accelerate neurodegeneration, making their modulation a critical therapeutic target

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Briefly, a 24-well culture plate was coated with 200 l (9.1 mg/ml)/well Matrigel prepared from Engelbreth-Holm-Swarm mouse tumors (Corning, MA, USA) and allowed to stand for 30 min at 37 C to form a gel layer

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