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Juices in the stomach break the GSH molecule into its three constituting amino acids glutamate, L-cysteine, and glycine which must then be reassembled into GSH

Thus, ascorbate reductases like MDHARs, which are responsible for the reduction of AsA have considerable roles in stress tolerance

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Oxidation of methionine can generate two diastereomeres that are reduced by two different non-related enzyme families, namely MSRA (reducing methionine- S -sulfoxide) and MSRB (reducing methionine- R -sulfoxide) [52]

While ETC activity drives pro-ferroptotic ROS generation via electron leakage, it is also essential for anti-ferroptotic enzymes (e.g., DHODH and GPD2) that reduce mitochondrial coenzyme Q (CoQ) to ubiquinol (CoQH 2 ) (113115)

Plates were read at 405 nm using a Tecan Sunrise Microplate reader (Tecan, Morrisville, NC, USA)