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This was attributed to spermidines ability to activate mitophagy and autophagy, helping maintain mitochondrial quality and preventing the accumulation of damaged mitochondria in heart tissue (Reference Eisenberg, Abdellatif and Schroeder80)

Interestingly, gating of SKOR is tightly regulated by its substrate concentration at either side of the membrane (Figure 1)

doi: 10.1080/15287399409531852

This in turn permits to increase the diffusion of Pt ions and reverts platinum drug resistance 93

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