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This reduction in GPx and GST activities would lead to a decrease in GSH synthesis, which would affect many essential metabolic pathways in which GSH is involved

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For instance, a previous study indicated that inhaled pan-JAK inhibitor LAS194046 reduced allergen-induced airway inflammation and late asthmatic response in a rat model, highlighting the potential of localized JAK inhibition to mitigate lung inflammation without significant systemic exposure [140]

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