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Wright WF, Riedel DJ, Talwani R, Gilliam BL

10.1038/nrendo.2018.22 122 RiveraJ

As shown in Table 3, the unique properties of nanomaterials have led to the rapid development of metal-based cell death pathways in HNSCC treatment

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(2019) Role of GPX4 in ferroptosis and its pharmacological implication, Free Radic

Activation of HIF-1 signaling by PHD2 deletion under normoxia enhanced glutamine uptake and upregulated GLS1 expression leading to enhanced glutaminolysis and increases in cellular GSH levels and in GSH/GSSG, which correlated with upregulation of antioxidant genes ( SOD1 , SOD2 , catalase , GPx1 , and GR ) and reduction in cellular and mitochondrial ROS production, indicatives of reductive stress (96)