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Studies indicate that lncRNAs Erbb4-IR and LRN9884 participate in renal fibrosis and inflammation during DN progression by influencing Smad3 activity ( Aberrant microRNA (miRNA) expression plays a key role in vascular injury mechanisms within DN

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This synaptic damage may have been brought on by reduced I-serine synthesis in the glycolytic branch

Nat Rev Cancer 20(1):1225 Wasilewski D et al (2017) Reactive astrocytes in brain metastasis

Given the central role of hepatic GSH in systemic GSH homeostasis, four liver disorders (cholestasis, endotoxemia, alcohol and fibrosis) where decreased GSH synthesis may participate in the pathogenesis of liver injury are described in more detail

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