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Vitam Horm 119:241274 ( Elsevier ) Kuijpers TW, de Vries AC, van Leeuwen EM, Ermens AT, de Pont S, Smith DE, Wamelink MM, Mensenkamp AR, Nelen MR, Lango Allen H, Pals ST (2022) Megalobastic anemia, infantile leukemia, and immunodeficiency caused by a novel homozygous mutation in the DHFR gene

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Mechanism: gene expression modulation upregulating antioxidant enzymes (SOD, catalase), reducing oxidative damage to RPE and photoreceptors

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Additional research has focused on the relationship between NNMT activity and nicotinamide metabolism, methyl donor utilization, and cellular signaling networks associated with energy balance

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