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Thus, the authors demonstrate the presence of GSTM1-1 in liver and conclude that the alkylation and potential irreversible inactivation of this isoform in vivo could contribute to an understanding of the hepatotoxicity associated with zileuton [55]

[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Stockwell B.R., Friedmann Angeli J.P., Bayir H., Bush A.I., Conrad M., Dixon S.J., Fulda S., Gascn S., Hatzios S.K., Kagan V.E., et al

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Encephalopathy, which results in coloration in many basal ganglia regions including the globus pallidus, subthalamic nuclei, and cranial nerve nuclei, can be caused by both CNS types 1 and 2 [52]

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Pep-pedia lists all three routes