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Isolation of speciofoline Kratom plant material (K52, 1 kg) was extracted exhaustively with 2 L of CHCl 3 /CH 3 OH (1:1) and 50 mL of KOH (10%) by maceration over 24 h at room temperature

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Additionally, the early post-operative period carries its own risks of nausea, vomiting, and gastrointestinal symptomsside effects that overlap significantly with those of GLP-1 and GIP/GLP-1 medications

Each signature was queried against the CMap using the algorithm described by Lamb et al .[13]