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How may these results be clinically translated

The New Book of Knowledge Medicine And Health

Curr Opin Toxicol 10:3136

These single-targeted approaches are insufficient to address the complex and tightly integrated pathophysiology of CMS

98 Although berberine has been studied in human clinical trials and shown to have several metabolic benefits, concerns about long-term use of berberine have been raised on the basis of certain preclinical studies