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123,124 Astrocytes are estrogen targets, 125 as both ER1 and ER2 receptors are present on the astrocyte membrane or intracellularly in astrocytes

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Tumor cells also depend on glutaminolysis, which can feed the mitochondrial TCA cycle and pentose phosphate pathway and thereby contribute to synthesis of fatty acids, nonessential amino acids, and nucleosides [9]

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Several studies have optimized urea-containing compounds such as SBI-797812 and 1-(2-phenyl-1,3-benzoxazol-6-yl)-3-(pyridin-4-methyl)urea (DS68702229) as potent NAMPT activators, which have been shown to increase NAD + levels in vitro and in vivo, with potential applications in treating metabolic disorders, cardiovascular diseases, and neurodegeneration preclinically 221,222