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Nielsen ML, Pareek M, Andersen I

The critical role of PGRN and TMEM106B in brain aging is also supported by mouse genetic studies, where deletion of either Grn or Tmem106b gene is reported to cause accelerated accumulation of lipofuscin in the brain [88, 89]

While their overall trends showed no significant discrepancies in interpretation, from a methodological perspective, it is advisable to select identical brain regions for investigation