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doi: 10.4161/onci.21176 80 CarlinoFDianaAPiccoloAVentrigliaABrunoVDe SantoIet al

The same inhibitor also countered age-related cartilage loss in animals and improved joint function

The animal experiment employed only female BALB/c mice

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324 mTORC1 also promotes purine synthesis via the transcription factors ATF4, MYC and FOXK1, 177,299 which control a variety of metabolic enzymes that contribute to purine biosynthesis

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