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Digestive issues: Creatine has been reported to cause some mild digestive issues, such as diarrhoea or stomach pain, particularly when taken in high amounts, but may cause complications if left unattended

Abnormal activation of pathways or obstruction of autophagic flux may lead to functional imbalance

(1992) published foundational work in the Journal of Molecular Endocrinology characterizing Long R3 IGF-1's enhanced potency in cell proliferation assays compared to native IGF-1

These genes are so highly conserved throughout evolution that counterparts were readily identified through homology searches in plants, fungi, and mammals (reviewed in Lill 2009