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Curcumin mitigated the effect of chronic ethanol intake on mouse liver, partly by upregulating Nrf2 target genes coding for NQO-1, HO-1, glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) (26)

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We also noted that GSK3 and GSK3 are priming-dependent kinases recognizing substrates with a pre-existing phosphoserine present 4 residues downstream of their target serine (ter Haar et al, 2001)