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Ueno N, Takeya R, Miyano K, Kikuchi H, Sumimoto H

We hereafter refer to this repetitive sequence set as WAGO-repeats as they are targeted by Ascaris WAGO Argonautes

It primarily manifests as motor symptoms due to the degeneration of dopamine-producing neurons in the substantia nigra pars compacta (SNpc), including tremors, bradykinesia (slowness of movement), muscle rigidity, and impaired coordination

This induction often occurs via activation of Nrf2 (Nuclear factor erythroid 2-related factor 2), a key transcription factor in the antioxidant response pathway

doi: 10.1158/1541-7786.MCR-06-0069

Tumor cells with high GGT expression demonstrate notable oxidative stress tolerance without DNA damage, while clones with low GGT expression exhibit increased sensitivity to oxidative stress and apoptosis (93)