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While the role of lipid-uptake by MM cells and any functional consequences is unclear, recent studies demonstrate that myeloma-associated bone marrow adipocytes undergo lipolysis, associated with the uptake of secreted free fatty acids by adjacent MM cells (69, 70, 72)

F h (liver) F h is what survives the first pass effect (E h ), hence F h = 1 E h E h = CL / Q h (CL: hepatic clearance

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Clinical trials with platinum drugs Despite the increasing exploration of alternative therapies, hundreds of studies published last year alone highlight ongoing clinical trials using platinum-based drugs, typically in combination with other treatments, for cancer therapy

Y.et al (2019)