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Pattern recognition proteins (PRPs) like surfactant proteins A and D, mannose binding lectin, C1q, C-reactive protein, and IgM natural antibodies function as components of the innate immune system through the recognition of pathogen-associated molecular patterns (PAMPs) (e.g., RNA viruses) and damage-associated molecular patterns (DAMPs) (e.g., apoptotic cells) and subsequent facilitation of foreign particle clearance by alveolar macrophages and other macrophages in different tissues

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In vitro , adequate Se concentrations decreased apoptosis and oxidative stress markers and increased proliferation and testosterone production of sheep Leydig cells by affecting p-ERK1/2 signaling, steroidogenic enzyme activities, and miR-200a/NRF antioxidant pathway (168)

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However, this should be approached cautiously and only after extended plateaus (6+ weeks of stable weight despite consistent protocol adherence)