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Redox-sensitive micelles co-deliver TMZ/ -lapachone to GBM, cleaving disulfides in GSH-rich tumors, whereas pH triggers endosomal escape (142)

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For example, HDIVC (50 mg/kg every 6 h for 96 h) failed to improve outcomes in vasopressor-treated septic ICU patients, instead increasing death or persistent organ dysfunction without secondary benefits (Lamontagne et al., 2022)