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By incorporating miRNA structures into gene therapy agents, it aims to inhibit the production of the mutant Z-AAT protein and promote the production of functional A1AT (79)

When RPL15 is overexpressed, the number of nucleoli and the expression of nucleolar proteins increases, and the abnormal increase in nucleolar size and number caused by dysregulation of ribosome biosynthesis is a hallmark of most spontaneous cancers [47]

Therefore, the interaction between SIRT1 and miR-34 plays a significant role in mediating the anti-cancer effects of 0404 in liver neoplasm [122]

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Similarly, consumption of pomegranate juice by trained cyclists resulted in increased time to exhaustion and time to reach the ventilatory threshold (Reference Torregrosa-Garca, vila-Ganda and Luque-Rubia92)