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This is because it is water-soluble, so most ingested B12 is actually flushed out in the urine

[3] For example, someone with borderline thiamine and B deficiency might feel less brain fog, improved mood, and better stamina as those vitamins are replenished

[33, 34] The most well-known is vitamin D deficiency, which can cause bone and joint pain, as well as a host of other symptoms

Several patients describe it as "the volume on everything bad got turned down." This isn't euphoriait's the absence of the low-grade malaise that low testosterone creates

Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, et al

Tirzepatide (Zepbound) is also FDA-approved for chronic weight management (with criteria) and has strong trial evidence for substantial average weight loss