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Evidence suggests that a shortage of glutathione is a main factor, and research into Parkinsons disease is telling

TangHYHoHYWuPRChenSHKuypersFAChengMLet alInability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance

In mice, FGF21 deletion increases sucrose intake, whereas FGF21 administration or overexpression suppresses consumption of sweetened food and beverages (276, 277)

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