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A randomized, placebo-controlled study in 52 subjects (mean age, 30 years) with relapsing-remitting multiple sclerosis found an increase in total antioxidant capacity in blood with lipoic acid supplementation (1,200 mg/day for 12 weeks) yet not in the activity of specific antioxidant enzymes (superoxide dismutase and glutathione peroxidase) (97)

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To build on our previous findings with ex vivo longitudinal spinal cord slice cultures (Hawker et al., 2024), we next looked at lysolecithin (LPC) to model sustained demyelination in ex vivo brain slice cultures