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Glomerular endothelial cells (GECs) are specialized vascular cells found in the kidney that help maintain renal homeostasis by forming the walls of the glomerular tufts

Nevertheless, the discovery of an extra-hepatic IGF-I production in the following years[18, 45], made it necessary to spand the conception of the GH/IGF-I axis, being well accepted nowadays that pituitary GH is able to induce IGF-I synthesis in both liver (~75%) and other tissues[23, 46, 47], which subsequently, is able to act in an endocrine/paracrine/autocrine manner

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doi: 10.1007/s12017-013-8219-0 254 Vias-JornetM.Esteba-CastilloS.BaenaN.Ribas-VidalN.RuizA.Torrents-RodasD.et al