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Topical effects are usually mild and local: redness, tingling, dryness, or transient irritation, more common above 4% concentration

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Importantly, this inhibition occurred without bactericidal effects on gut microbiota, as confirmed by preserved alpha diversity and the persistence of TMA-producing genera such as Collinsella and Clostridium post-treatment

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GIP is a hormone that may complement the effects of GLP-1 receptor agonism