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In these cases, symptoms can remain even after successful repositioning treatment and movement of the canaliths or debris which were lodged in the posterior or horizontal semicircular canals

De Filippis B, Valenti D, Chiodi V et al (2015) Modulation of Rho GTPases rescues brain mitochondrial dysfunction, cognitive deficits and aberrant synaptic plasticity in female mice modeling Rett syndrome

One placebo-controlled, double-blind, cross-over trial in 86 subjects with fertility issues found that supplementation with L-carnitine (2 g/day) for two months improved sperm quality, as evidenced by increases in sperm concentration and motility (111)

Chen, M

Key symptoms include pain, numbness, stiffness, and muscle spasms (Velasco et al., 2019

Indeed, in a model of graft-versus-host disease (GVHD), T-cell-depleted bone marrow transplants fed with TMAO-rich diet exhibited a significant increase in the frequency of F4/80 + CD11b + CD16/32 + inflammatory macrophages relative to the F4/80 + CD11b + whole population, worsening disease severity, and increasing mortality ( Figure 3 Beyond the inflammatory response, choline metabolism is also implicated in IL-4-induced macrophage polarization, critical for immunity against intestinal helminth infection, resolution of inflammation, and tissue repair