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Cuproptosis occurs via copper binding to lipoylated enzymes in the tricarboxylic acid (TCA) cycle, which leads to subsequent protein aggregation, proteotoxic stress, and ultimately cell death

doi: 10.3945/jn.112.173229 CrossRef Google Scholar View reference in article 82 NalumansiP

This disconnect occurs because folate transport across the blood-brain barrier is impaired

In contrast, in in vivo assay, xCT-KO pancreatic ductal adenocarcinoma (PDAC) cells injected subcutaneously managed to form a tumor, although with a short delay