Johns wort simultaneously inhibits the reabsorption of 5-HT, NE, and DA with similar effectiveness ( via inhibiting the transporter (67)
Consequently, intraocular oxygen tension in the eye rises, leading to oxidation of the trabecular meshwork, which leads to a recalcitrant form of open-angle glaucoma (think of aphakic glaucoma) that is refractory to medical therapy and often requires surgery

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roseus extract contains bioactive substances, including polyphenols acting as antioxidants
This process culminated in the inclusion of approximately 180 publications that formed the evidence base for this comprehensive review
Functional morphology of the bloodbrain barrier in health and disease