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B12 supplementation can mitigate this fatigue, especially in those whose lab work confirms deficiency or borderline status

A third person may not be a good candidate at all

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In contrast, congenital pernicious anemia, often caused by mutations in the GIF gene, which encodes intrinsic factor, manifests in infancy or early childhood with profound vitamin B12 malabsorption, leading to severe megaloblastic anemia and developmental delays