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Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma

The therapeutic approach centers on isoform-selective inhibitors or genetic silencing, complemented by pathway co-targets that feed these enzymes (e.g., angiotensin/PKCNOX axes) and precision delivery to the relevant plasma-membrane, endosomal, or nuclear microdomain to avoid off-target suppression of host defense (Cipriano et al

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Eicosanoid Eicosanoids are signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, similar to arachidonic acid, around 20 carbon units in length

The weight loss itself accounts for some of this effect, but GLP-1 receptor activation also appears to have direct anti-inflammatory and anti-fibrotic effects in liver tissue

PubMed Central PMCID: PMC8154420