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The anti-inflammatory effects protect blood vessel walls from the chronic inflammation that drives atherosclerosis

10.1016/j.freeradbiomed.2018.09.008 131 SuX.LiuK.XieY.ZhangM.WangY.ZhaoM.et al (2019)

Interestingly, the addition of hGSTs results in major changes in the regioselectivity of GSH conjugation of the reactive clozapine metabolite, possibly due to the different active site geometries of hGSTs [33]

doi:10.1111/j.1834-7819.2007.tb00460.x

10.1016/j.cell.2010.10.026 Cell 66 JacksonS.XiongY

MAT2A inhibitors AG-270 and IDE-397 have demonstrated significant antitumor activity both in vitro and in animal models, and phase I clinical trials are currently underway