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M1 and M2 represent two phenotypes in macrophages with completely opposite functions, The former is characterized by high expression of pro-inflammatory cytokines, including IL-1, IL-6, IL-12, and TNF-, while the latter predominantly produces anti-inflammatory cytokines like IL-10 and TGF- (Shapouri-Moghaddam et al., 2018)

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10.1016/j.niox.2017.03.003 50 FormanowiczD.MalinskaA.NowickiM.KowalskaK.Gruca-StryjakK.BreborowiczG.et al (2019)

Qiu X, Wang A, Wang J, Zhang Z, Tao L (2025) Mitochondrial metabolic reprogramming in colorectal cancer, mechanisms of resistance and future clinical interventions