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Studies using human iPSC-derived cell types have indicated that the presence of neuronal ApoE4 leads to more extensive tau phosphorylation and cell death compared to ApoE3 (Therriault et al., 2020)

Findings imply that 4-MESC has an antidepressant-like action since it can significantly ameliorate the behavioral despair of depressed animals (Figures 4A, B)

After 6 h, 50 L solution was taken out and the HAc/NaAc buffer (0.5 M, pH = 4.5) was added, then followed by addition of H 2 O 2 (31 M), FeSO 4 (33.2 M), DCFH-DA (1:1000) or TMB (1.2 mM), respectively

Exp Neurol 211:480488

What that evidence does and does not license The precise reading matters

References Zhou W, et al