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The TRX antioxidant system is comprised of both TRX and thioredoxin reductase (27, 48, 175, 418)

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however, p53 3RK failed to induce cell cycle arrest, senescence, or modulation and inhibited xCT expression, ultimately promoting the response to stress induced by ROS (68)

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Hepcidin is an iron-regulatory hormone that induces degradation of ferroportin and negatively regulates iron efflux

a MASLD, metabolic dysfunction-associated steatotic liver disease