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It is becoming increasingly evident that mammalian cells can modulate patterns of protein expression in response to hydroperoxide stress, by activating redox-sensitive transcription factors such as Egr-1, NF- B and AP-1, G-proteins and by activating cellular kinases such as the mitogen-activated protein kinase (MAPK) family.18 This oxidative-dependent cellular signalling pathways alteration may frequently lead, with a still unknown mechanism, to hepatocyte apoptosis

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There is a need for a multi-level approach that considers not only individual decisions but also environmental, economic, and cultural determinants of reproductive health [22, 23]

2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

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