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doi:10.1002/mnfr.201500019

The documented research protocol is once daily: 150 mcg from the 10 mg vial, or 2.5 mg from the 50 mg vial

Most patients begin to notice the effects in 24 to 72 hours , depending on how deficient they are and what symptoms theyre experiencing

R 2 , R 3 , R 4 , and R 5 are independently selected from the group consisting of: H, C 1-4 alkyl, halogen-substituted C 1-4 alkyl, NR 9 R 10 , and CN