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Weight-based chemotherapy dosing in obese patients with cancer: back to the future

Upregulation of cyclin dependent kinase inhibitor 1A(CDKN1A)/p21 by p53 contributed to the reduced sensitivity to ferroptosis in cancer cells

Rossella Cannarella, lead investigator on the study, this dual action means tirzepatide could become a first-line treatment option for men whose testosterone issues are rooted in metabolic health, rather than structural damage to the testes