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Salicylic acid (0.5-2%) and retinoids work by dissolving the keratin plugs blocking hair follicles, but can actually worsen yeast conditions by increasing skin cell turnover that feeds Malassezia

Due to their high water content, structural similarity to natural tissues, and favorable biocompatibility, hydrogels are widely used in biomedical fields, particularly for drug delivery, facilitating controlled release and enhancing efficacy (198200)

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The defects in mitochondrial metabolism and respiration are dependent on a block in pyruvate metabolism, as respiration was restored with pyruvate supplementation (Fu et al., 2015)

The target is to improve the overlay of the drug and release kinetics and prolong the shelf lifespan of the drug with fewer side effects

(Anusree et al