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Another mechanism leading to methotrexate resistance is elevated production of DHFR resulting from an increase in the number of copies of the DHFR gene (gene amplification) (see Fig

Rings may contain one oxygen or sulfur, one to three nitrogen atoms, or one oxygen or sulfur combined with one or two nitrogen atoms

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Multiple techniques, including genomic, proteomic, transcriptomic, and target-specific investigations, have been employed to determine the factors affecting biofilm formation

The study identified a regulatory axis (VDAC3/DHODH) that enhances GSH-mediated ferroptosis resistance, demonstrating significant cardioprotective outcomes in vivo (Wang J