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Saudi Pharm J 26:876885

Another study in 2019 indicated that NIN reduced -SMA and Smad3 protein and mRNA levels and blocked oxidative stress, inflammation and the TGF--Smad3 and JNK-Smad3 pathways, thereby carrying out its antifibrotic effects (Hernndez-Aquino et al., 2019)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Guerra I.M.S., Ferreira H.B., Melo T., Rocha H., Moreira S., Diogo L., Domingues M.R., Moreira A.S.P