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J Biol Chem 244:15521562

The study has been performed in accordance with the Declaration of Helsinki

Owing to the involvement of Gln in GSH synthesis, we detected changes in intracellular GSH and reactive oxygen species (ROS)

NAC has been previously shown to rescue DPI-induced cell death (16), however, in the present experiments it failed to protect against the (M+D)/2 and (M+D+V)/3 combinations and instead further enhanced toxicity