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It leads to a decrease in its mRNA expression level and reduces the synthesis of triglyceride (TG) and lipid-toxic intermediate products (Winarto et al., 2023)

However, the N-terminal portions of COP1, including the G/S-rich domains, RING-domain and coiled-coil domain, were unresolved, suggesting that only the WD40 domains are stabilized by interactions with the DDD-E2 complex

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This could explain why the lymphoid cell lines are more susceptible to polyphenol/topoisomerase II inhibitor treatment compared with the myeloid cell lines

The crystal structure of GPX4 (PDB id: 6NH3) was obtained from the RCSB Protein Data Bank (PDB, The 3D structures of PCBP1 and PCBP2 were predicted by Alph-Fold