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Or is it to do with the sheer amount of work B12 has to do in the body

HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers

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Howard JM, Azen C, Jacobsen DW, Green R, Carmel R

And the breakthrough cases we see are by and large in the extremely elderly or people who are severely immunocompromised and were not able to achieve adequate protection from their first vaccine doses