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John Myers in the 1950s for patients who were not responding to oral supplements

Nitric Oxide Synthase (eNOS/iNOS) Pathway Regulation Stimulates NO production through eNOS/iNOS activation : BPC-157 upregulates nitric oxide synthesis in vascular tissue and restores endothelial homeostasis, as shown in ischemic and inflammatory models 3,4

Worbs, T

10.1016/j.nbd.2016.07.007 Neurobiol

Additionally, the increase in hemichannel activation due to an increase in pro-inflammatory cytokines [e.g., tumor necrosis factor- (TNF-) and interleukin-1 (IL-1)] in primary cell cultures and mice results in an increase in the release of various ions (i.e., K + , Ca 2+ ) and gliotransmitters (i.e., ATP, glutamate) into the extracellular space, further disrupting homeostasis and possibly contributing to neuronal death (Retamal et al., 2007

It seems there is no real logic apart from the fact that vitamin C is present in some of them