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Cationic chitosan, COS, and their derivatives have been widely accepted as agents that induce opening of corneal epithelial tight junctions [46], thereby facilitating intraocular drug delivery

However, its important to note that many other more common conditions, including taking certain medications, are more likely to be the culprit: for example, a lack of dietary intake, taking medications for acid reflux or diabetes or an autoimmune condition, she adds

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The first developed metformin prodrug, namely its cyclohexyl sulfenamide derivative, was in part activated on the apical side of the enterocytes with consequent decrease of absorbtion 121