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Recently, the Pacold group identified 4-HPPA dioxygenase-like protein (HPDL) as the enzyme responsible for this transformation, using ^18O 2 gas labeling and metabolomics techniques 29

mSphere 10 (8), e00029-25

Pretreatment of SM exposed guinea pigs with doxycycline resulted in the reduction of gelatinases activity (MMP-2 and MMP-9), decreased lung inflammation (cellularity and protein levels in BAL), and decreased lung pathological changes (epithelial lesions) (63)

Sarkar S, Panikker P, D'Souza S, Shetty R, Mohan RR, Ghosh A

Lipid peroxide accumulation is inhibited by glutathione peroxidase 4 (GPX4), a lipid hydroperoxidase that uses reduced GSH as a cofactor (Friedmann Angeli et al, 2014

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