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This response is characterised by upregulation of several cytoprotective and detoxification genes, including ferritin, GSH- S -reductase (GSR), GST, GCLM, and GCLC, phase-I drug oxidation enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1), MRP, and heme oxygenase-1 (HO-1) [78, 79]

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It acts as an agonist at GLP-1, GIP, and glucagon receptors

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Redox Biol 56:102459

The representative synthetic compound targeting Nrf2 is melatonin, an amine hormone secreted by the brains pineal gland [203]